Research Article

A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

Figure 1

Sex-dependent effects of high-fat diet on body mass and on fasted blood glucose. (a) Males on the HFD gained significantly more weight by week 6 and continued to do so for the remainder of the experiment compared to their CD counterparts. After 15 wk on the diets, control fed males outweighed control fed females by 44%, while HFD fed males outweighed HFD fed females by 50%. Ingesting the HFD did not significantly increase female body weight (; ; ). (b) Male HFD fed rats had significantly elevated fasting blood glucose compared to both control males and HFD females (), while no differences were observed between the dietary groups in female rats.