Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain

<div><i>Stat</i> (<i>Stat1</i>,<i> Stat3</i>,<i> Stat4</i>,<i> Stat5a</i>, and<i> Stat5b</i>) gene expression in C57BL/6J mouse whole brain throughout development presented in each anatomical region with <svg height="12.6721pt" id="M1" style="vertical-align:-3.38377pt" version="1.1" viewbox="-0.0498162 -9.28833 82.646 12.6721" width="82.646pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M238 0V26C174 32 166 38 166 104V712C132 700 70 683 18 677V653C81 647 87 645 87 577V104C87 38 78 32 15 26V0H238Z" id="g121-106"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="253" vert-adv-y="253"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,3.289,0)"><path d="M257 449C165 449 37 374 37 209C37 98 119 -12 256 -12C355 -12 473 65 473 226C473 349 381 449 257 449ZM244 416C333 416 380 320 380 204C380 67 329 21 267 21C184 21 130 115 130 241C130 354 184 416 244 416Z" id="g121-109"></path><glyph.data 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vert-adv-y="547"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,77.806,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z" id="g113-42"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g></svg>.<i> Jak</i> gene expression data are not available. RSP: rostral secondary prosencephalon; Tel: telencephalic vesicle; PedHy: peduncular (caudal) hypothalamus; p3: prosomere 3; p2: prosomere 2; p1: prosomere 1; M: midbrain; PPH: prepontine hindbrain; PH: pontine hindbrain; PMH: pontomedullary hindbrain; MH: medullary hindbrain (medulla). Allen Developing Mouse Brain Atlas 2013 (<a href="http://developingmouse.brain-map.org/">http://developingmouse.brain-map.org/</a>).</div>

Neural Plasticity

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Figure 2

Figure 2: Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain 