Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Figure 1

Metaplasticity. The induction threshold of LTP and LTD can be modified as a consequence of overall past synaptic or intrinsic activity of postsynaptic neurons. Such compensatory adjustment called “metaplasticity” provides stability to neuronal networks that support Hebbian synaptic plasticity. (a) LTP induction by conventional high frequency stimulation (HFS) is favorable in the neurons whose previous synaptic and intrinsic activities were low. (b) LTD induction by conventional low frequency stimulation (LFS) is favorable in the neurons whose previous synaptic and intrinsic activities were high.

(a)

(b)