Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Figure 2

Aberrant metaplasticity in AD. Aβ increases the activity of excitatory neurons, which in turn stimulates synthesis and release of Aβ in a positive feedback loop, leading to pathologic accumulation of Aβ. Neuronal hyperexcitability or early activation of GluN2B-containing NMDAR by heightened Aβ expression induces aberrant metaplasticity, leading to inhibition of LTP by HFS and enhancement of LTD in the hippocampus by LFS or normal LTD induction by subthreshold LFS.