Correlation between Motor Cortex Excitability Changes and Cognitive Impairment in Vascular Depression: Pathophysiological Insights from a Longitudinal TMS Study
Table 2
Single-pulse TMS parameters obtained from patients and controls at baseline.
VD
VCI
Controls
Kruskal-Wallis ANOVA
(2,42)
Left hemisphere
rMT (%)
47.2 ± 9.8
47.4 ± 9.0
43.0 ± 5.5
2.86
0.238
CSP (ms)
86.4 ± 38.3
93.2 ± 37.0
71.0 ± 16.6
3.22
0.200
MEP latency (ms)
19.6 ± 1.8
20.4 ± 1.3
20.3 ± 1.6
1.64
0.439
CMCT (ms)
5.7 ± 1.0
5.3 ± 0.4
6.0 ± 1.0
4.81
0.090
CMCT-F (ms)
5.3 ± 0.9
5.4 ± 0.8
5.9 ± 0.8
4.20
0.122
A ratio
0.4 ± 0.1
0.4 ± 0.1
0.3 ± 0.1
1.91
0.384
F amplitude (μV)
0.1 ± 0.1
0.1 ± 0.0
0.1 ± 0.1
1.96
0.375
Right hemisphere
rMT (%)
46.1 ± 9.6
44.1 ± 6.2
42.9 ± 4.6
1.54
0.463
CSP (ms)
97.1 ± 48.3
91.5 ± 36.8
67.7 ± 22.8
3.52
0.171
MEP latency (ms)
19.7 ± 1.7
20.1 ± 1.6
19.9 ± 1.6
0.62
0.732
CMCT (ms)
5.7 ± 0.8
5.5 ± 0.4
5.7 ± 1.0
0.13
0.936
CMCT-F (ms)
5.3 ± 0.7
5.5 ± 1.0
5.6 ± 1.1
0.51
0.775
A ratio
0.5 ± 0.2
0.4 ± 0.1
0.4 ± 0.1
1.24
0.538
F amplitude (μV)
0.1 ± 0.1
0.2 ± 0.1
0.1 ± 0.1
3.98
0.137
VD, patients with vascular depression; VCI, patients with vascular cognitive impairment-no dementia; rMT, resting motor threshold; CSP, cortical silent period; MEP, motor evoked potential; CMCT, central motor conduction time; CMCT-F, central motor conduction time estimated with the F wave latency; A ratio, CMAP/MEP amplitude ratio.
