Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity

Figure 1

Schematic representation of BAI family members. BAI adhesion-GPCRs have a diverse collection of signaling and structural domains. These include thrombospondin type I repeats (TSRs), a hormone binding domain (HBD), the GAIN domain (GAIN), the GPCR autoproteolysis site (GPS), the characteristic seven-transmembrane domain (7TM), an α-helical RKR motif (HD), and the PDZ-binding motif (PBM), which are shared between all three family members. BAI1 has five TSRs, while BAI2 and BAI3 only have four. BAI1 and BAI2 are cleaved by proteases (BAI1 by matrix metalloprotease-14, BAI2 by Furin), which generates truncated fragments at the indicated locations marked by arrows. BAI1 has an additional integrin-binding RGD motif in the N-terminus and a proline-rich region (PRR) in the C-terminus. BAI1 also has a slightly truncated third intracellular loop compared to the other family members. BAI3 has a unique CUB domain in the N-terminus.