K_V1 and K_V3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat

Figure 6

Additive effects of 1 specific-isoforms blockers on PPR. This figure shows the recordings from a single slice sequentially exposed to several blockers. An additive effect was observed on PPR (left panels) and traces taken at the times indicated on the PPR plot (right panel). In (a) 1.2 blockage with tityustoxin (TyTx) induces a reduction in PPR that remains with little change despite addition of 1.2/1.3-blocker margatoxin (MgTX) and 1.1/1.2/1.2-blocker hongotoxin (HgTx); however addition of 1.2/1.3/1.6-blocker dendrotoxin (DTx) produced a second reduction of PPR. (b) Addition of MgTx to block 1.2/1.3 channels produced a drop in PPR comparable to that observed with TyTx. Further addition of TyTx and HgTx did not alter PPR. Once again DTx induces a second steep reduction.

(a)

(b)