Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse

Figure 3

Single burst stimulation (SBS) results in bidirectional plasticity. Top: SBS induction protocol. (a) Individual experiment resulting in LTP. Control mean 5.1 mV; long-term mean 9.4 mV (dashed lines). Inset shows averaged response to SBS stimulation. (b) Individual experiment resulting in LTD. Control mean 6.2 mV; long-term mean 4.9 mV (dashed lines). Inset shows averaged response to SBS stimulation (same scale as in (a)). (c) Cumulative data (normalized to control) of SBS experiments with substantial LTP (solid triangles, ) and substantial LTD (open triangles, ). All data points ± SD across experiments. From the second data bins after induction onwards, bins were significantly different from the respective last data bins before induction. and refer to the statistical comparison between the last data point before induction and the second data point after induction for LTP (black triangles) and LTD (open triangles), respectively. (d) Cumulative display of control mean EPSP amplitudes versus the long-term change of individual experiments normalized to control of individual experiments. Open circles: experiments without action potentials (APs) during SBS; filled circles: experiments with APs during SBS. The two experiments shown in (a, b) are indicated by their SBS averages and arrows.