mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits

Figure 1

Systemic administration of MTEP attenuates context-primed relapse following abstinence and extinction learning. (a) Mean infusions during the self-administration period did not differ between groups later given MTEP or vehicle during the relapse test. (b) MTEP (0.5–5 mg/kg i.p.) significantly decreased responding on the previously active lever while not affecting inactive lever pressing. (c) Administration of MTEP prior to relapse test (R, extinction day 1) did not significantly alter extinction responding on the following days (no group differences on days 2–5). compared to Veh.

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