Research Article

Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo

Table 1

Comparison of in vivo transduction efficiency in different cell types and cochlear regions four days after injection of three adenoviral vectors into P0 or P4 mouse cochleae. per condition. Apical: apical turn of the cochlea, basal: basal turn of the cochlea, IHCs: inner hair cells, middle: middle turn of the cochlea, OHCs: outer hair cells, P0: injected at postnatal day 0, P4: injected at postnatal day 4, and SCs: supporting cells.

Transduction efficiency (%)IHCsOHCsSCs
BasalMiddleApicalBasalMiddleApicalBasalMiddleApical

Ad-Cre-GFP-BaylorP074.5 ± 8.670.6 ± 7.8
P454.4 ± 6.852.4 ± 6.93.8 ± 1.2
Ad-GFP-BaylorP09.1 ± 1.280.0 ± 12.090.8 ± 9.284.7 ± 10.6
P413.6 ± 2.917.4 ± 4.279.1 ± 10.674.3 ± 11.242.3 ± 6.1
Ad-GFP-VBP09.1 ± 1.515.0 ± 4.89.8 ± 1.829.0 ± 4.927.8 ± 4.141.5 ± 8.17.7 ± 2.9
P42.9 ± 0.951.1 ± 6.233.1 ± 4.2