A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer’s Disease

Figure 1

(a) Box- and violin-plots for the AOO of AD by gender (top), early-onset (middle), and level of education (bottom) in 60 patients carrying the PSEN1 E280A  mutation. The associated value after testing for differences in the average AOO is shown. AOO: age of onset; AD: Alzheimer’s disease; EOAD: early-onset Alzheimer’s disease. (b) Filtering workflow of exonic variants leading to the selection of 71 variants harboured in genes associated with modifiers of the AOO of AD in carriers of the PSEN1 E280A mutation as reported by Vélez et al. [18]. Abbreviations as in (a). (c) Partition of phenotypic variance for each forward inclusion (steps 1 to 10) and backward elimination (10 steps after the dotted line). The yellow vertical line marks the model selected based on the lowest Bayesian Information Criterion (BIC).