Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

Figure 1

Neurons in all regions of the human hippocampus expressed aromatase (tissue obtained from an 89-year-old woman without any known neurological disease). (a–d) Immunohistochemical staining (DAB) for aromatase resulted in a strong signal in all hippocampal regions. (e–j) Coimmunostaining for aromatase (e, h) and the neuronal marker MAP2 (f, i) demonstrated that primarily hippocampal neurons expressed aromatase. Aromatase-expressing neurons are orange in the overlay, and nuclei were stained blue with DAPI (g, j). Images were taken from the CA1 region (e–g) and the CA3 region (h–j). Scale bar: 50 μm; CA: cornu ammonis; DG: dentate gyrus.