Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

Figure 2

Aromatase expression was higher in the hippocampi of brains from patients with AD than in control brains. (a, b) Immunohistochemical staining in the CA4 region of postmortem hippocampi from a patient diagnosed with AD (b) and a sex- and age-matched control (a) (scale bar: 20 μm). (c) Semiquantitative analysis of aromatase immunoreactivity, expressed as the relative staining index, demonstrated that in most cases aromatase reactivity was higher in the hippocampi obtained from AD brains than in the sex- and age-matched control hippocampi. The numbers for each matched pair refer to Table S1 (sample numbers 1–10) (, , ; bars represent mean ± SEM).