(a)
(b)
(c)
(d)
Figure 5: Young female 5xFAD mice showed less aromatase immunoreactivity than WT mice. In both hippocampal regions tested, CA1 and CA3, the relative staining index for aromatase was significantly lower in the 3-month-old female 5xFAD mice than in the WT mice (a). This difference was no longer detectable in the 12-month-old females (b). In male animals, overall the relative staining index for aromatase tended to be higher in the male 5xFAD mice; however, none of the differences was significant (c, d) (, ; bars represent mean ± SEM, ).