Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands

Table 2

Effect of an acute administration of cannabinoid receptor ligands on oxidative stress biomarkers in the whole brains of mice. Data are presented as the means ± SEM; –12; , , and   versus vehicle-treated control group; Tukey’s test.

Drug (dose)	TAC	SOD	MDA
	[mmol Fe/mL tissue]	[U/mg protein]	[μM/g wet w.]
Vehicle	249.3 ± 28.54	2.458 ± 0.1279	0.596 ± 0.027
JWH 133 (0.5 mg/kg)	275.7 ± 21.79	2.516 ± 0.1131	0.653 ± 0.029
JWH 133 (1.0 mg/kg)	385.1 ± 32.20	2.894 ± 0.1422	0.915 ± 0.056
JWH 133 (2.0 mg/kg)	404.0 ± 31.68	2.648 ± 0.1071	0.817 ± 0.080
AM 630 (0.5 mg/kg)	271.7 ± 19.89	2.349 ± 0.1267	0.611 ± 0.047
AM 630 (1.0 mg/kg)	327.4 ± 30.87	2.367 ± 0.1219	0.905 ± 0.094
AM 630 (2.0 mg/kg)	401.0 ± 32.44	2.505 ± 0.1371	0.880 ± 0.065
AM 630 (3.0 mg/kg)	446.4 ± 35.02	2.532 ± 0.1475	0.616 ± 0.030
WIN 55,212-2 (1.0 mg/kg)	418.8 ± 33.27	2.610 ± 0.1434	0.850 ± 0.059
AM 251 (1.0 mg/kg)	343.3 ± 25.83	2.437 ± 0.1258	0.900 ± 0.063
AM 251 (3.0 mg/kg)	371.5 ± 21.88	2.513 ± 0.1773	0.897 ± 0.078