Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

Figure 2

The activation of noncanonical Wnt pathways stimulates the glycolytic rate in cortical neurons. (a) Treatment with Wnt5a stimulates the HK activity in a time-dependent manner (i), and this effect was blocked by coincubation with FzdCRD-2 and 7NI (ii). (b) Incubation with Wnt5a stimulates the glycolytic rate (i); this effect was blocked by coincubation with 7NI and FzCDR-2 and stimulated in a concentration-dependent manner by the NO donor SNP ((ii) and (iii)). (c) Treatment with Wnt5a by 2 h increases ATP production; this effect was blocked by the coincubation with FzdCRD-2. Data represent the mean ± SEM of , each performed in triplicate. ; , Bonferroni test.

(a)

(b)

(c)