Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

Figure 5

Schematic representation of the effect of Wnt5a over the glucose metabolism in cortical neurons. The Wnt5 stimulates the glucose uptake and the activity of the HK. Downstream the Wnt5a stimulates the glycolytic rate and PPP activity, in a NO-dependent manner. The increase in the glycolytic rate was correlated with an increase in the generation of ATP. The increase in the PPP activity (through the production of the cofactor NADPH) could be correlated as a mechanism against the oxidative stress generated by the increase in the mitochondria activity.