In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

<div>PNNs in the human amygdala. (a) PNN labeled with<i> wisteria floribunda</i> agglutinin (WFA) lectin, which binds to N-acetyl-galactosamine on the terminal end of chondroitin sulfate chains. (b) PNN immunolabeled using the mAB antibody 3B3 against native chondroitin sulfate motifs specific for chondroitin-6-sulfate (CS-6). 3B3-immunolabeled PNNs are more numerous and show a much broader distribution in the human amygdala with respect to those labeled with WFA. (c) PNN immunolabeled with mAB antibody 1B5, raised against nonsulfated chondroitin sulfate (CS-0) (3B3 and 1B5 are a generous gift from Dr. Bruce Caterson, University of Cardiff, UK). Scale bar = 50 <i>μ</i>m.</div>

Neural Plasticity

fig1

Figure 1

Figure 1: In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders 