Short Latency Gray Matter Changes in Voxel-Based Morphometry following High Frequent Visual Stimulation

Figure 3

Possible physiological connection between short latency and long-latency voxel-based morphometry (VBM) alterations based on water shifts. Neuronal activation following flickering checkerboard stimulation goes along with immediate water depended changes of cell volume that could be detected as short latency gray matter changes in VBM paradigms. Persistent water alterations induce long-term downstream effects leading to cell proliferation and apoptosis that might reflect the long-latency gray matter changes in VBM paradigms (for review [5]).