Table of Contents Author Guidelines Submit a Manuscript
Neural Plasticity
Volume 2017, Article ID 1612078, 9 pages
Research Article

Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study

1Faculty of Humanities, Research Unit of Logopedics, Child Language Research Center, University of Oulu, Oulu, Finland
2Center for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, Italy
3Department of Psychology, University of Turin, Turin, Italy
4Neuroscience Institute of Turin, Turin, Italy
5Brain Imaging Group (BIG), Koelliker Hospital, Turin, Italy
6Psychiatric Service, Mental Health Department, ASL-TO3, Turin, Italy
7CCS fMRI, Koelliker Hospital, Turin, Italy

Correspondence should be addressed to Francesca M. Bosco; ti.otinu@ocsob.acsecnarf

Received 20 July 2016; Revised 4 November 2016; Accepted 7 December 2016; Published 23 January 2017

Academic Editor: Preston E. Garraghty

Copyright © 2017 Ilaria Gabbatore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia. Methods. The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain. Behavioural measures of the patient’s communicative performance were also gathered before and after training and at follow-up. Results. The patient improved his communicative performance in almost all tests. Posttraining stronger ALFF signal emerged in the superior, inferior, and medial frontal gyri, as well as the superior temporal gyri. Conclusions. Even if based on a single case study, these preliminary results show functional changes at the cerebral level that seem to support the patient’s behavioural improvements.