A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity

Figure 2

Renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), and heart rate (HR) responses to microinjection of leptin with/without preadministration of AP5 in the PVN or ARCN. ^# versus control group without AP5 administration. (a) A representative tracer of RSNA, MAP, and HR responses to microinjection of leptin with/without preadministration of AP5 in the PVN; bar = 1 min. (b) Mean changes in RSNA, MAP, and HR to microinjection of leptin (5–100 ng) with preadministration of AP5 (16 pmol) in the PVN or ARCN. ^# versus leptin group without AP5.

(a)

(b)