Modulation Effects of Cordycepin on Voltage-Gated Sodium Channels in Rat Hippocampal CA1 Pyramidal Neurons in the Presence/Absence of Oxygen

Table 1

Preapplication of cordycepin-induced mild inhibition on I_Na attenuated and delayed the subsequent hypoxia-induced rapid dramatic inhibition of I_Na. (Recordings were collected after 3 min hypoxia.)

Groups	INa amplitude (% of initial)	Descending slope (mV/min)	Inactivation, V1/2 (mV)	Recovery time (ms)
Control ()	96.8 ± 3.8		−47.4 ± 3.7	1.48 ± 0.06
Cordycepin ()	77.6 ± 4.58^##		−54.8 ± 4.1^#	2.10 ± 0.14^#
Hypoxia ()	50.6 ± 5.12^##	15 ± 0.11	−55.9 ± 3.9^#	2.21 ± 0.12^#
Cordycepin + hypoxia ()	66.3 ± 5.53^,##	4.6 ± 0.32	−54.3 ± 3.8^#	2.26 ± 0.14^#

Descending slope means the inhibition rate induced by hypoxia from 0 to 3 min; and compared to the hypoxia group; ^# and ^## compared to the control group.