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Neural Plasticity
Volume 2017 (2017), Article ID 2545736, 9 pages
Review Article

Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants

1ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France
2Radiopharmacy Department, CHU Toulouse, Toulouse, France
3LAAS-CNRS, Université de Toulouse, CNRS, INSA, UPS, Toulouse, France
4Nuclear Medicine Department, CHU Toulouse, Toulouse, France

Correspondence should be addressed to Isabelle Loubinoux

Received 7 June 2017; Revised 19 September 2017; Accepted 23 October 2017; Published 17 December 2017

Academic Editor: Zhong-Ping Feng

Copyright © 2017 Alice Le Friec et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential in the clinic. We will also discuss new avenues of stem cell therapy in patients with a cerebral lesion. A promising future for the development of efficient drugs to enhance functional recovery after stroke seems evident. These drugs will have to prove their efficacy also in severely affected patients. The efficacy of stem cell engraftment has been demonstrated but will have to prove its potential in restoring tissue function for the massive brain lesions that are most debilitating. New answers may lay in biomaterials, a steadily growing field. Biomaterials should ideally resemble lesioned brain structures in architecture and must be proven to increase functional reconnections within host tissue before clinical testing.