Treadmill Exercise Improves Motor Dysfunction and Hyperactivity of the Corticostriatal Glutamatergic Pathway in Rats with 6-OHDA-Induced Parkinson’s Disease

Figure 9

Comparison of evoked latency of striatal neurons after cortical stimulation. The latency was significantly decreased in the PD compared to the control group. Note that the latency in PD + Ex rats is significantly attenuated by treadmill exercise; exercise can reverse 6-OHDA-induced hyperactivity of the corticostriatal glutamatergic pathway. Control: control group; control + Ex: control plus exercise group; PD: Parkinson’s disease group; PD + Ex: Parkinson’s disease plus exercise group; 6-OHDA: 6-hydroxydopamine.