The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury

Table 1

Different strategies to promote regeneration using FGF1.

Species	Model	Therapeutic intervention	Outcome	Control	Ref
Rat	Complete transection at T8.; Removal of 5 mm of SC.	Autologous peripheral nerve implant with glue containing FGF1. Routing of regenerative pathway from white matter to grey matter.	Improvement on open field walking score from 0.5 to 3. Axon regeneration beyond the graft. Fewer GFAP poor holes between the stumps.	Transection only.; Cord removal only. White matter-to-white bridging.; Omission of FGF1.	[67]
Rat	Complete transection at T8.; Removal of 5 mm of SC.	Autologous peripheral nerve implant with glue containing FGF1.	Improvement on BBB from 1 to 7. Partial restoration of sensory function.	Transection only, laminectomy only.; Transection and peripheral nerve graft and matrix fibrin matrix without FGF1. Transection and FGF1 fibrin matrix.	[68]
Nude rat	Mid-thoracic SC transection.	Human Schwann cell graft with FGF1 fibrin glue at the injury-graft boundary and delayed FGF1 fibrin glue at the dorsal surface of the guidance channel.	Axon regeneration into the graft. Maximum termination density closer the host-graft interface. Less axonal die-back.	Schwann cell graft without FGF1.	[69]