The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury

Table 3

Combination therapy.

Species	Model	Therapeutic intervention	Outcome	Control	Ref
Rat	T10 complete transection	18 intercostal segments (peripheral nerve autografts (PNGs)) soaked with ChABC and covered by FGF1-laden fibrin matrix, plus ChABC injection in the interface of graft and host.	Significantly better bladder function.; Regeneration of 5-HT and TH positive fibres into and beyond the graft	Laminectomy only.; Transection only.; Transection plus PNG.; Transection plus FGF1 and ChABC.; Transection plus PNG and ChABC.; Transection plus PNG	[76]
Rat	Unilateral pyramidotomy	Overexpression of FGFR1 via AAV1 injections into the unlesioned CST	No difference between FGFR1 overexpressing animals and control animals	Injection of AAV1 overexpressing mCherry	[77]