Identification of TMPRSS3 as a Significant Contributor to Autosomal Recessive Hearing Loss in the Chinese Population

Figure 2

Conservation analysis of TMPRSS3 mutations and genomic structure of TMPRSS3 based on the open reading frame (NM_024022.2). Protein alignment showing conservation of residues TMPRSS3 Ile270, Met384, Gly402, Leu415, and Gly417 across nine species. All mutations occurred at evolutionarily conserved amino acids or areas (in red box) in trypsin-like serine protease domain. TM: transmembrane domain; LDLRA: LDL receptor-like domain; SRCR: scavenger receptor cysteine-rich domain; serine protease: trypsin-like serine protease domain.