Research Article
Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus
Figure 1
Acute TPPU and 14,15-EET applications increased excitatory synaptic transmission at the Schaffer collateral-CA1 hippocampal synapses. (a) Effects of TPPU (0.05, 0.1, and 1 μM) administration on fEPSP response. (b) Effects of 14,15-EET (1, 10, and 30 nM) administration on fEPSP response. (c) Effects of 20-HETE (1, 5, 10, and 50 nM) administration on fEPSP response. Data represent means ± SEM in each experiment ( from 5 mice). , compared with vehicle group; scale, 40 ms and 0.5 mV.
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