Research Article

Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus

Figure 3

TPPU and 14,15-EET facilitated FSK-induced LTP. (a) Effect of FSK (25 μM) on the fEPSP response in hippocampal neurons. (b) Effects of TPPU and 14,15-EET on FSK-induced LTP. (c) Comparison of the effects shown in (a) and (b). (d) Effects of TPPU and 14,15-EET on FSK-induced LTP in the presence of DPCPX (500 nM). (e) Effects of TPPU and 14,15-EET on FSK-induced LTP in the presence of 2-CADO (1 μM). (f) Bar chart comparing the effects of TPPU and 14,15-EET on FSK-induced LTP in the presence or absence of DPCPX and 2-CADO. Data represent means ± SEM in each experiment (). versus FSK alone. ### versus DPCPX group; scale, 40 ms and 0.5 mV.
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