A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1

Figure 6

WFM attenuated capsaicin-induced response in CCI-treated sensory neurons. (a) Representative calcium images in cultured DRG neurons from CCI contralateral and ipsilateral. WFM and GBPT could significantly inhibit the responses of DRG neurons from CCI ipsilateral to 500 nM capsaicin. (b) The percentage of reactive neurons to 500 nM capsaicin stimulus. The percentage of DRG neuron response to 500 nM capsaicin stimulus was significantly higher in the ipsilateral (CCI) than in the contralateral (control). WFM and GBPT could significantly reduce the response percentage of DRG neurons to the same concentration of capsaicin stimulus. (c) The amplitude of the response neurons to 500 nM capsaicin stimulus. The amplitude of DRG neurons response to 500 nM capsaicin stimulus was significantly larger in the ipsilateral (CCI) than in the contralateral (control). Both WFM (high dose and low dose) and GBPT could effectively inhibit capsaicin-induced response. (d) Calcium imaging response curves of DRG neurons to different stimulus. White arrows indicate these active neurons. , , .

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