Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies

Figure 6

The number of proliferating cells in the GLOM, GCL, and OT of the OB was very low and not altered in AD, PDD/DLB, or FTLD compared to controls. Representative images depicting proliferating cells expressing the marker MCM2 in the GLOM, GCL, and OT in a control (a) and in FTLD ((b) case #5336), with higher magnification of typical doublet of MCM2+ cells (insert). The quantification of MCM2-positive cells revealed no significant difference between controls and AD, PDD/DLB, or FTLD for GLOM and GCL, as well as for the OT (c). 1-way ANOVA, for all groups. Scale bar represents 50 μm.

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