White Matter Hyperintensity Load Modulates Brain Morphometry and Brain Connectivity in Healthy Adults: A Neuroplastic Mechanism?

Table 2

Positive association between WMHs and brain structure and functional connectivity.

Cluster-level pFWE	Cluster extent (voxels)	score at local maximum	Brodmann area	Side	Brain region	Talairach coordinates
						x	y	z
Regional grey matter volume
0.045	875	4.67	10	R	Superior frontal gyrus	33	51	22
		4.59	10	R	Middle frontal gyrus	45	47	16
		3.69	10	R	Inferior frontal gyrus	46	52	1
		3.64	10	R	Superior frontal gyrus	34	57	16
		3.33	10	R	Superior frontal gyrus	26	56	3
		3.22	10	R	Superior frontal gyrus	30	61	6
<0.001	3149	4.67	8	R	Superior frontal gyrus	10	43	44
		4.54	32	L	Medial frontal gyrus	−6	12	45
		4.50	8	R	Superior frontal gyrus	12	37	46
		3.98	6	R	Superior frontal gyrus	10	23	61
		3.96	8	L	Medial frontal gyrus	−2	25	43
		3.82	9	L	Medial frontal gyrus	−4	50	34
		3.74	6	L	Superior frontal gyrus	−18	22	56
		3.69	32	R	Middle cingulate cortex	3	36	28
		3.59	6	R	Superior frontal gyrus	2	26	56
		3.35	8	L	Superior frontal gyrus	−14	36	53
		3.33	6	L	Superior frontal gyrus	−20	17	62
		3.21	9	L	Superior frontal gyrus	−6	56	27
Anterior default-mode network
0.046	240	3.77	29	L	Posterior cingulate cortex	−16	−42	8
		3.51		L	Hippocampus	−26	−39	2
		3.40	37	L	Fusiform gyrus	−34	−36	−13
		3.38	36	L	Parahippocampal gyrus	−34	−32	−10
		3.29	19	L	Parahippocampal gyrus	−36	−49	−1
		3.23		L	Hippocampus	−32	−35	−7
		3.11		L	Hippocampus	−24	−37	−3
Salience network
0.028	267	4.00	3	R	Postcentral gyrus	26	−34	55
		3.56	40	R	Inferior parietal lobule	34	−48	56
		3.31	7	R	Superior parietal lobule	26	−51	63
		3.26	40	R	Inferior parietal lobule	32	−40	52
		3.06	7	R	Superior parietal lobule	32	−51	62
		3.02	3	R	Postcentral gyrus	20	−30	59

L: left; R: right; FWE: family-wise error.