Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Figure 2

Differences showing the effects of stress/ antidepressant treatments on depressive-like behaviors in depression rats induced by CUMS. (a) The effects of stress/antidepressant treatments on the body weight in depression rats induced by CUMS. (b) The effects of stress/antidepressant treatments on the sucrose intake levels in depression rats induced by CUMS. (c) The effects of stress/antidepressant treatments on the horizontal motion scores in depression rats induced by CUMS. (d) The effects of stress/antidepressant treatments on the vertical motion scores in depression rats induced by CUMS. Differences are shown as follows: ^★ versus control group; ^★★ versus control group; ^▲ versus model group; ^▲▲ versus model group; ^◆ versus acupuncture group; ^◆◆ versus acupuncture group; ^■■ versus fluoxetine group. Values are given as for 10 rats in each group. Acu: acupuncture group; FLX: fuoxetine group; Acu + H89: Acupuncture + H89 group; FLX + H89: Fluoxetine + H89 group.

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