Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Figure 3

The effectiveness and validity of ICV catheterization. (a) The fixed position of ICV catheterization. (b) The rat subjected to effective ICV catheterization. (c) The structure and morphology of bilateral paracele detected with the naked eye. The bilateral paracele was suffused with blue substance after ICV injection of 1% Evans blue, suggesting the validity of ICV injection and ICV catheterization. (d) The structure and morphology of bilateral paracele screened under the fluorescence microscope. The wall of the whole bilateral paracele, including frontal, occipital, temporal and inferior horn, was suffused with Evans blue exhibiting red fluorescence.

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