Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway
Table 2
Differences showing the effects of stress/antidepressant treatments on depressive-like behaviors in depression rats induced by CUMS.
(a) Differences in body weight following stress/antidepressant treatments
Group
n
0 days
21 days
Control
10
277.01 ± 11.10
363.83 ± 38.06
Model
10
275.24 ± 12.75
319.61 ± 17.95★★
Acu
10
281.42 ± 17.26
348.04 ± 31.05▲
FLX
10
271.93 ± 20.34
350.99 ± 30.49▲
Acu + H89
10
256.58 ± 15.01★★,▲▲,◆◆
257.86 ± 28.48★★,▲▲,◆◆
FLX + H89
10
250.37 ± 11.57★★,▲▲,■■
252.73 ± 31.61★★,▲▲,■■
(b) Differences in sucrose intake levels following stress/antidepressant treatments
Group
n
0 days
21 days
Control
10
22.96 ± 2.52
36.71 ± 8.04
Model
10
24.57 ± 2.98
22.52 ± 5.92★★
Acu
10
24.80 ± 3.50
29.29 ± 7.99★,▲
FLX
10
25.97 ± 4.64
33.51 ± 5.17▲▲
Acu + H89
10
25.19 ± 2.59
20.52 ± 4.57★★,◆◆
FLX + H89
10
25.12 ± 1.98
13.39 ± 6.92★★,▲▲,■■,
(c) Differences in horizontal and vertical motion scores following stress/antidepressant treatments
Group
0 days
21 days
Horizontal
Vertical
Horizontal
Vertical
Control
65.10 ± 13.01
12.10 ± 4.04
50.70 ± 13.84
18.40 ± 8.76
Model
66.60 ± 14.04
10.00 ± 3.53
9.50 ± 4.97★★
2.10 ± 1.29★★
Acu
65.80 ± 14.40
10.80 ± 2.90
18.10 ± 7.37★★,▲
5.80 ± 1.81★★,▲▲
FLX
65.20 ± 13.74
10.30 ± 4.01
16.90 ± 5.30★★,▲
6.10 ± 2.23★★,▲▲
Acu + H89
58.20 ± 13.66
9.20 ± 3.12
10.20 ± 8.20★★,◆
1.20 ± 1.03★★,◆◆
FLX + H89
58.70 ± 12.69
9.50 ± 2.76
5.30 ± 3.80★★,▲,■■
1.50 ± 1.27★★,■■
Acu: acupuncture group; FLX: fluoxetine group; Acu + H89: Acupuncture + H89 group; FLX + H89: Fluoxetine + H89 group. Results are presented as for 10 rats in each group. Differences are shown as follows: ★ versus control group; ★★ versus control group; ▲ versus model group; ▲▲ versus model group; ◆ versus acupuncture group; ◆◆ versus acupuncture group; ■■ versus fluoxetine group; versus Acu + H89.
