Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice

Figure 2

SNAP-25 cKO mice exhibit schizophrenia-like phenotype. (a–d) Summary plots of velocity, movement trajectory, stereotype movement in the open-field test (), and reduced prepulse inhibition (). (e) cKOs display deficient social skills as shown by social approach-avoidance test (). (f) cKOs occupy an impaired tendency to explore novel environment in hole-board test (). (g) Nest building. Left panel: pictures show the results of nesting of different genotypic mice. Right panel: statistical results of nesting scores (). (h) cKOs display impaired learning and memory in the step-through passive avoidance task (). , , and compared with control littermates.

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