Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Figure 2

The bidirectional relationship between the circadian clock and alcohol. (a) The circadian clock modulates alcohol sensitivity and alcohol consumption. Alcohol acts upon circadian oscillators to affect phase shifting of oscillators as well as expression patterns of circadian genes leading to circadian dysfunction. (b) The master circadian clock in the brain modulates the behavioral sensitivity to alcohol including hyperactivity, sedation, recovery, and tolerance. (c) Alcohol affects the master circadian clock in the SCN as well as in peripheral oscillators in the liver, kidney, and heart.

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