Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Table 2

Genes that mediate circadian and alcohol interactions.

Fly ortholog	Encoded protein	Genetic manipulation	Drosophila alcohol-related phenotypes	Mammalian homolog	References
per^01	PER	↓ expression	↑ alcohol sensitivity; ↓ rapid tolerance; ↑ recovery time	mPer1; mPer2	[202, 290, 291, 294, 299, 301, 318]
tim^01	TIM	↓ expression	↑ alcohol sensitivity; ↓ rapid tolerance	—	[294]
cyc^01	CYCLE	↓ expression	↑ alcohol sensitivity; ↓ rapid tolerance	BMAL	[30, 294]
Clk^JRK	CLOCK	↓ expression	No change	CLOCK	[294, 434]