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Gene/manipulation | Mechanism of action | Drug-related phenotypes in Drosophila | Reference | Drug studied in mammals | Reference |
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per01 | Regulation of circadian rhythms | ↓ behavioral sensitization to cocaine | [334] | mPer1 and mPer2: cocaine, morphine, and amphetamines | [324, 326, 336, 435, 436] |
clk | Regulation of circadian rhythms | ↓ behavioral sensitization to cocaine | [334] | Clk: cocaine, morphine, and amphetamines | [324, 336, 437, 438] |
cyc01 | Regulation of circadian rhythms | ↓ behavioral sensitization to cocaine | [334] | Bmal: cocaine and amphetamine | [324, 336, 436] |
tim01 | Regulation of circadian rhythms | No change in response to cocaine | [334] | — | — |
dbt | Regulation of circadian rhythms | ↓ behavioral sensitization to cocaine | [334] | Csnk1𝜀: cocaine, amphetamines, and opiods | [439–442] |
dLmo | Regulation of dopamine receptor expression | ↑ sensitivity to cocaine and nicotine and weak circadian rhythms in locomotor activity | [333] | Lmo4: cocaine | [338, 443] |
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