HINT1 in Neuropsychiatric Diseases: A Potential Neuroplastic Mediator

Figure 3

The pattern of HINT1 interacting with GPCRs. (a) HINT1 interacts with the C-terminus of μ-opioid receptor (MOR). HINT1 also interacts with the NR1 subunit of NMDAR. To prevent opioids from producing an excessive reduction of neuronal excitability, NMDARs are recruited to the MOR environment, where they become activated to restrain opioid signaling. In this context, HINT1 stabilizes the functional interaction between MOR and NMDAR. (b) HINT1 may also associate with cannabinoid receptor type I (CNR1). CNR1 can negatively regulate NMDAR function when the receptor is coupled to HINT1.

(a)

(b)