The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation

Figure 1

The biphasic effect of BPA on LTP in rat dentate gyrus in vitro. (a) High-frequency stimulation induced LTP in the medial perforant path of the dentate gyrus of acute rat hippocampus slices (open circles, ). Applications of BPA are indicated at concentrations of 10 nM (filled squares, ), 100 nM (filled circles, ), and 1000 nM (open squares, ), respectively. All hippocampal slices were preperfused with ACSF, 30 min before HFS, to obtain baseline EPSP amplitude. (b) Summary of the major experimental outcomes. The average fEPSP amplitudes at 60 min after HFS in separate perfusion of different concentration BPA. Applications of BPA 100 nM and BPA 1000 nM have significant effects on LTP, , as compared to controls. Solid and dashed example traces before HFS and after HFS, respectively.

(a)

(b)