The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation

Figure 2

The enhancement of BPA on hippocampal LTP was ER-dependent. (a) Administration of ICI 182,780 10 nM (an antagonist of ERs, filled square, ) remarkably decreased the 100 nM BPA-induced enhancement of LTP. Pretreatment with the ERs antagonist ICI 182,780 30 min before BPA 100 nM (open squares, ) application completely blocked BPA-enhanced LTP compared with BPA alone. (b) Figure columns express the average fEPSP amplitudes after HFS in separate perfusion or coperfusion of BPA 100 nM and ICI 182,780 100 nM, as compared to the control, as compared to the BPA 100 nM. Solid and dashed example traces before HFS and after HFS, respectively.

(a)

(b)