Neural Plasticity / 2017 / Article / Tab 1 / Research Article
Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains Table 1 Summary of NSC proliferation, differentiation, and number of mature neurons across mouse strains, and efficacy of integration into mature neurons from proliferating NSCs and differentiating neuroblasts. (
per group);
indicates a significant difference between the sedentary and exercise groups (
), and
indicates a significant difference between the sedentary and exercise groups (
). Data are shown as mean ± SEM. NSC: neural stem cells.
Strains CB7BL/6J A/J BALB/c C3H/HeJ FVB 129/SvJ DBA/1 DBA/2 ICR Total increase % Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Ki-67 SED 20.00 ± 1.58 11.60 ± 0.24 8.00 ± 0.32 9.80 ± 1.46 8.40 ± 0.93 10.00 ± 0.89 8.00 ± 0.71 2.40 ± 0.51 9.00 ± 1.22 Proliferation EX 32.20 ± 2.97 18.20 ± 0.86 12.40 ± 1.03 16.40 ± 2.48 13.00 ± 0.95 18.60 ± 0.93 12.60 ± 1.44 3.40 ± 0.98 16.20 ± 0.86 Increase % 161.00 156.90 155.00 167.35 154.76 186.00 157.50 141.67 ns 180.00 162.24 DCX SED 122.80 ± 4.86 73.60 ± 2.91 47.20 ± 2.40 73.40 ± 1.12 60.00 ± 2.77 79.20 ± 5.34 45.40 ± 4.79 31.00 ± 4.18 71.60 ± 5.91 Differentiation EX 210.2 ± 4.89 108.6 ± 2.94 68.4 ± 3.49 97.2 ± 7.44 82.2 ± 6.26 127.2 ± 2.48 73.00 ± 1.10 45.20 ± 4.31 97.8 ± 3.62 Increase % 171.17 147.55 144.92 132.43 137.00 160.61 160.79 145.81 136.59 148.54 BrdU/NeuN +/+ SED 21.20 ± 1.81 8.00 ± 1.05 5.00 ± 0.55 6.40 ± 1.03 6.00 ± 0.55 7.80 ± 0.73 4.40 ± 1.25 2.20 ± 0.37 12.40 ± 0.51 Maturation & survival EX 31.00 ± 2.18 15.60 ± 1.69 10.80 ± 1.50 11.60 ± 1.21 9.00 ± 0.55 12.80 ± 1.65 9.80 ± 0.58 4.00 ± 0.77 18.20 ± 1.74 Increase % 146.23 195.00 216.00 181.25 150.00 164.10 222.73 181.82 ns 146.77 160.39 CB7BL/6 J A/J Balb/c C3H/HeJ FVB 129/Svj DBA/1 DBA/2 ICR Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Mean SE Efficacy of cell maturation SED-BrdU + NeuN/Ki67 106.00 ± 16.61 69.09 ± 9.16 63.17 ± 7.70 72.99 ± 18.17 76.31 ± 11.45 78.14 ± 3.55 56.39 ± 16.57 125.00 ± 46.10 154.08 ± 32.48 85.59 EX-BrdU + NeuN/Ki67 96.27 ± 13.39 85.32 ± 7.87 91.78 ± 16.63 75.12 ± 11.02 70.51 ± 5.91 69.09 ± 8.97 80.87 ± 7.48 136.43 ± 20.40 113.38 ± 11.96 88.56 EX/SED % 90.82 123.49 145.28 102.93 92.40 88.42 143.41 109.14 73.59 108.65 SED-BrdU + NeuN/DCX 17.26 ± 1.34 11.04 ± 1.65 10.60 ± 0.98 8.70 ± 1.39 9.96 ± 0.70 9.79 ± 0.36 9.80 ± 2.84 7.80 ± 1.71 17.70 ± 1.31 10.79 EX-BrdU + NeuN/DCX 14.75 ± 10.64 14.34 ± 1.48 16.10 ± 2.47 12.16 ± 1.40 11.12 ± 0.82 10.06 ± 1.32 14.63 ± 0.87 8.62 ± 0.87 18.78 ± 2.16 12.96 EX/SED % 85.43 129.95 151.85 * 139.72 111.63 102.75 149.40 * 110.52 106.13 121.57
