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Neural Plasticity
Volume 2017 (2017), Article ID 6303512, 7 pages
Research Article

Localizing Age-Related Changes in Brain Structure Using Voxel-Based Morphometry

1College of Psychology and Sociology, Shenzhen University, Shenzhen 518060, China
2Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China
3Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China
4Shenzhen University Health Science Center, Shenzhen, China

Correspondence should be addressed to Jian Zhang and Li Hai Tan

Received 4 March 2016; Revised 12 August 2016; Accepted 15 September 2016; Published 17 January 2017

Academic Editor: Stuart C. Mangel

Copyright © 2017 Shu Hua Mu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods. Method. The structural MRI of 91 normal individuals ranging in age from 6 to 26 years was obtained and the GMV for each region was measured. Results. Our results showed that the earliest loss of GMV occurred in left olfactory, right precuneus, caudate, left putamen, pallidum, and left middle temporal gyrus. In addition, the trajectory of maturational and aging showed a linear decline in GMV on both cortical lobes and subcortical regions. The most loss of gray matter was observed in the parietal lobe and basal ganglia, whereas the less loss occurred in the temporal lobe and hippocampus, especially in the left middle temporal pole, which showed no decline until 26 years old. Moreover, the volumes of GM, WM, and CSF were also assessed for linear age effects, showing a significant linear decline in GM with age and a significant linear increase in both WM and CSF with age. Interpretation. Overall, our findings lend support to previous findings of the normal brain development of regional cortex, and they may help in understanding of neurodevelopmental disorders.