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Neural Plasticity
Volume 2017 (2017), Article ID 6373412, 12 pages
Review Article

Circadian Plasticity of Mammalian Inhibitory Interneurons

1Department of Histology, Jagiellonian University Medical College, 7 Kopernika Street, 31-034 Krakow, Poland
2Department of Cell Biology and Imaging, Institute of Zoology, Jagiellonian University, 9 Gronostajowa Street, 30-387 Krakow, Poland

Correspondence should be addressed to Elzbieta Pyza

Received 29 August 2016; Revised 15 January 2017; Accepted 19 February 2017; Published 6 March 2017

Academic Editor: Stuart C. Mangel

Copyright © 2017 Malgorzata Jasinska and Elzbieta Pyza. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inhibitory interneurons participate in all neuronal circuits in the mammalian brain, including the circadian clock system, and are indispensable for their effective function. Although the clock neurons have different molecular and electrical properties, their main function is the generation of circadian oscillations. Here we review the circadian plasticity of GABAergic interneurons in several areas of the mammalian brain, suprachiasmatic nucleus, neocortex, hippocampus, olfactory bulb, cerebellum, striatum, and in the retina.