Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity

Figure 2

SAM function and mechanisms. SAMs can recruit and organize protein interaction networks in the synaptic cleft by (a) generating mechanisms to recognize specific SAM partners, but not others by binding through direct interactions; (b) binding other SAMs to generate a scaffold onto which a third protein can dock and this mechanism also supports the binding of SAMs through indirect interactions; (c) binding a partner and inducing a signaling event, for example, through (allo)steric mechanisms.

(a)

(b)

(c)