Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity

Figure 3

SAMs can contribute to synaptic plasticity. SAM function can be regulated by synaptic activity through different processes. Protein levels can change (1) as a result of altered localization targeting a protein to or away from the synaptic membrane surface (1a), protein synthesis (1b), protein degradation (1c), and ectodomain shedding (1d). The availability of members within a broad portfolio of potential partners can be altered (2). SAMs can be diversified through alternative splicing (3). SAMs can be repositioned in the synaptic cleft (4). Protein interactions supported by SAMs can be modulated by astrocytic factors (5). Details are as discussed in the text.