Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity

Figure 4

Synaptic protein interaction network coordinated by neurexins. (a) Neurexins (blue ovals) bind many protein partners tethered to the postsynaptic membrane including neuroligins, LRRTMs, α-dystroglycan, calsyntenins (CLSTN), and the -receptor, as well as partners that are secreted such as neurexophilins. (b) NLGN1 and LRRTM2 can both bind neurexins at an overlapping binding site generating two competing trans-interactions. (c) Neurexins and MDGA1 can both bind NLGN2 at an overlapping binding site generating competing cis- and trans-interactions.

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(b)

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