Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism

Figure 1

(a) Schematic model of the mechanisms of the ephrin pathway in the control of CF-induced spine regulation in mature cerebellar PCs (see text). (b) The block of activity induces proliferation of spines expressing GluD2 and GABA receptors, atrophy and loss of contacts of the CF, and expansion of the PFs and GABAergic terminals to the proximal domain of PCs.

(a)

(b)