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Neural Plasticity
Volume 2017 (2017), Article ID 6971206, 7 pages
Research Article

Navigated Transcranial Magnetic Stimulation: A Biologically Based Assay of Lower Extremity Impairment and Gait Velocity

1Division of Occupational Therapy, The Ohio State University, Columbus, OH, USA
2B.R.A.I.N. (Better Rehabilitation and Assessment for Improved Neuro-recovery) Laboratory, Ohio State University, Columbus, OH, USA
3The University of Cincinnati, Cincinnati, OH, USA
4Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
5Nexstim, Ltd., Helsinki, Finland

Correspondence should be addressed to Heather T. Peters; ude.cmuso@yelsknat.rehtaeh

Received 29 December 2015; Revised 10 October 2016; Accepted 6 December 2016; Published 24 January 2017

Academic Editor: Guang H. Yue

Copyright © 2017 Heather T. Peters et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. (a) To determine associations among motor evoked potential (MEP) amplitude, MEP latency, lower extremity (LE) impairment, and gait velocity and (b) determine the association between the presence of a detectable MEP signal with LE impairment and with gait velocity. Method. 35 subjects with chronic, stable LE hemiparesis were undergone TMS, the LE section of the Fugl-Meyer Impairment Scale (LE FM), and 10-meter walk test. We recorded presence, amplitude, and latency of MEPs in the affected tibialis anterior (TA) and soleus (SO). Results. MEP presence was associated with higher LEFM scores in both the TA and SO. MEP latency was larger in subjects with lower LEFM and difficulty walking. Conclusion. MEP latency appears to be an indicator of LE impairment and gait. Significance. Our results support the precept of using TMS, particularly MEP latency, as an adjunctive LE outcome measurement and prognostic technique.